Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning.
نویسندگان
چکیده
Living-cell-based screens can facilitate lead discovery of functional therapeutics of interest. A versatile and scalable method is reported that uses dense arrays of nanowells for imparting defined patterns on monolayers of cells. It is shown that this approach can coordinate a multi-component biological assay by designing and implementing a high-throughput, functional nanoliter-scale neutralization assay to identify neutralizing antibodies against HIV.
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ورودعنوان ژورنال:
- Small
دوره 11 36 شماره
صفحات -
تاریخ انتشار 2015